Synthesis and Antiproliferative Properties of Bifunctional Allocolchicine Derivatives
| Autor: | Irina P. Beletskaya, Iuliia A. Gracheva, V. I. Faerman, Elena V. Svirshchevskaya, Alexey Yu. Fedorov |
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| Rok vydání: | 2018 |
| Předmět: |
biology
010405 organic chemistry Chemistry Organic Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences chemistry.chemical_compound Colchifoline Tubulin Cell culture Allocolchicine biology.protein Colchicine Antimitotic Agent Bifunctional Cytotoxicity |
| Zdroj: | Synthesis. 50:2753-2760 |
| ISSN: | 1437-210X 0039-7881 |
| DOI: | 10.1055/s-0037-1610146 |
| Popis: | Based on the natural antimitotic agent colchifoline as a lead structure, a series of novel bifunctional allocolchicine congeners were synthesized from commercial colchicine. The new derivatives maintain good cytotoxicity against T3M4, MiaPaCa-2, and PANC-1 cell lines. The presence of functional groups simplifies further modifications of the prepared structures and the design of novel colchicine-derived antitumor compounds with desired pharmacological properties. |
| Databáze: | OpenAIRE |
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