| Popis: |
Purpose: To study the effect of mitomycin-C (MMC) on the conjunctival epithelium after LASIK ablation. Methods: This preliminary study comprised 18 patients scheduled for LASIK to correct myopia. The patients were divided into 2 groups of 9 patients each. In Group 1, the flap was performed with a mechanical microkeratome (M2, Moria), wereas in Group 2 a femtosecond laser (IntraLase) was used. For each patient topical MMC 0.02% was applied on the right eye with a Merocell sponge for 60 seconds, over the bulbar superior conjunctiva covering an area of 64 mm2 before the surgery. Conjunctival goblet cell density was studied by impression cytology pre-operatively, and at one, two and three months after surgery. Results: Analysis by impression cytology of the ocular surface showed that preoperative goblet cell density was not significantly different between the eyes with and without MMC (G1: P=0.81 and G2: P=0.50).1 month after LASIK surgery there was a significant decrease in the goblet cell density in both groups (G1: P 0.62 and G2: P>0.08). Conclusions: Topical MMC 0.02% for 60 seconds over the bulbar conjunctiva before the LASIK surgery does not seem to affect the conjunctival goblet cell density in this preliminary study. |
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