| Autor: |
Jialin Gao, Jing Gu, Meng-xiang Qi, Xing Hu, Ying-ying Song, Hai-jun Liu, Ya-ting Zhang, Wen-xiu Wu, Ya-jun Wu, Jia-hao Xu, Jun-hao Wang, Jing-rong Li, Miao-miao Liu, Wen-jun Pei, Yao Zhang, Li-zhuo Wang |
| Rok vydání: |
2022 |
| Popis: |
β-cell dedifferentiation is important in the pathogenesis of type 2 diabetes, and the relationship between lysosome membrane proteins and pancreatic β-cell dedifferentiation is still unknown. Sidt2 is a lysosomal membrane protein identified in our previous study. After Sidt2 elimination, mice exhibited a diabetic phenotype. In the present study, we found that Sidt2 also can be considered a new insulin granule membrane protein. Sidt2 deficiency resulted in islet dysfunction and inhibited insulin secretion. The absence of Sidt2 also led to increased β cell dedifferentiation in mice. Further experiments showed that defects in insulin secretion caused dedifferentiation in the absence of Sid2. In summary, our study has found a new dedifferentiation regulatory mechanism mediated by a lysosomal membrane protein. This new secretory regulation pathway will enrich our understanding of the regulatory mechanisms involved in β cell dedifferentiation and provide new insights into the pathogenesis of diabetes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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