Dietary Restriction Extends the Lifespan of Circadian Mutants tim and per
| Autor: | Matt Ulgherait, Julie C. Canman, Miles K. Oliva, William W. Ja, Mimi Shirasu-Hiza, Anna Chen, Han X Kim |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Genetics Physiological function biology Physiology ved/biology Timeless media_common.quotation_subject Period (gene) ved/biology.organism_classification_rank.species Mutant Longevity Cell Biology biology.organism_classification 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Circadian rhythm Model organism Molecular Biology Drosophila 030217 neurology & neurosurgery media_common |
| Zdroj: | Cell Metabolism. 24:763-764 |
| ISSN: | 1550-4131 |
| DOI: | 10.1016/j.cmet.2016.11.002 |
| Popis: | Dietary restriction (DR), or decreased consumption of nutrients such as protein, extends lifespan in multiple model organisms, including Drosophila (Fontana and Partridge, 2015). In a recent article in Cell Metabolism, Katewa et al. (2016) presented evidence indicating that arrhythmic Drosophila females lacking the circadian regulators period (per) or timeless (tim) exhibit truncated lifespan extension in response to DR (Katewa et al., 2016). In Drosophila, Per and Tim proteins are critical regulators of circadian rhythm, or daily oscillations in activity and physiological function. |
| Databáze: | OpenAIRE |
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