| Popis: |
Inflammation is a dynamic process of plasma-derived and cellular events occurring in response to tissue injury or infection. The early stages of acute inflammation are characterized by the sequential release of mediators including histamine, 5-hydroxytryptamine (5-HT), kinins, prostanoids, substance P and nitric oxide (NO). Prostaglandins (PGs) and thromboxanes (TXs), collectively termed prostanoids, are biologically active molecules operative in both acute and chronic inflammation. They are formed from membrane-released arachidonic acid by a series of enzymes including cyclooxygenase (COX), alternatively named prostaglandin H synthase (PGHS), or prostaglandin endoperoxidase synthase. |
