Autor: | František Novák, B. Hamplova, Eva Tvrzická, Olga Novakova, Václav Pelouch |
---|---|
Rok vydání: | 2003 |
Předmět: |
endocrine system
medicine.medical_specialty endocrine system diseases Plasmalogen Clinical chemistry Chemistry Clinical Biochemistry Thyroid Phospholipid Cell Biology General Medicine Phosphatidylserine chemistry.chemical_compound Endocrinology medicine.anatomical_structure Internal medicine medicine Pi Euthyroid Phosphatidylinositol Molecular Biology hormones hormone substitutes and hormone antagonists |
Zdroj: | Molecular and Cellular Biochemistry. 252:295-303 |
ISSN: | 0300-8177 |
DOI: | 10.1023/a:1025557622452 |
Popis: | The aim of this study was to examine the effect of hypo- and hyperthyroidism on the phospholipid composition in developing rat heart. The hypothyroid state (PTU) was induced by 0.05% 6-n-propyl-2-thiouracil in drinking water given to nursing mothers from the postnatal day 2-21. The hyperthyroidism (T3) was made by daily injection of 3,3',5-triiodo-L-thyronine (10 microg/100 g body wt) to newborns in the same time period. Age matched intact littermates were taken as euthyroid controls. PTU decreased the concentration of total phospholipids (PL), choline phosphoglycerides (PC), ethanolamine phosphoglycerides (PE) and diphosphatidylglycerol (DPG) and increased the proportion of plasmalogen component of PE (PLPE). T3 increased the concentration of PL, PC, PE, DPG and decreased PLPE in comparison with euthyroid controls. The ratio of saturated/unsaturated fatty acids (FA) in PE was decreased in PTU and increased in T3 group. The ratio of n-6/n-3 polyunsaturated FA in PC, PE and phosphatidylinositol (PI) was increased in PTU due to increase of 18:2n-6 and decrease of 22:6n-3 proportion. T3 decreased this ratio because of decline in 20:4n-6 and rise in 22:6n-3 proportion. Both hypo- and hyperthyroidism decreased the ratio of 20:4n-6/18:2n-6 in the majority of phospholipids. PTU decreased the unsaturation index in PC, PI and phosphatidylserine. It is concluded that thyroid state plays an essential role in the development of membrane phospholipid components in cardiac membranes during the early postnatal period. |
Databáze: | OpenAIRE |
Externí odkaz: |