Visualization of Chiral Binaphthyl Recognition by Atroposelective Antibodies with Thermoresponsive Polymers

Autor:	Akira Harada, Hiroyasu Yamaguchi, Tomoki Odaka, Takuma Adachi
Rok vydání:	2017
Předmět:	biology 010405 organic chemistry medicine.drug_class Chemistry Stereochemistry General Chemistry 010402 general chemistry Monoclonal antibody 01 natural sciences 0104 chemical sciences medicine biology.protein Moiety Thermoresponsive polymers in chromatography Antibody
Zdroj:	Chemistry Letters. 46:1173-1175
ISSN:	1348-0715 0366-7022
DOI:	10.1246/cl.170296
Popis:	Chiral recognition of monoclonal antibodies (mAbs) to binaphthyl derivatives (BNs) is visualized utilizing poly-N-isopropylacrylamide (pNIPAM) bearing a BN moiety. The affinity of an anti-BN (S) antibody to BN (S) is retained even when BN (S) is attached to the center of the pNIPAM main chain. The addition of the anti-BN (S) antibody in an atroposelective manner suppresses the aggregation of pNIPAM-BN (S).
Databáze:	OpenAIRE
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