Temporally controlled transdermal system: biphasic transdermal delivery of nitroglycerin

Autor:	Bret Berner, Steven M. Dinh, Ihor Shevchuk, Ann Reese Comfort
Rok vydání:	1994
Předmět:	Drug Chemistry media_common.quotation_subject Filtration and Separation Aqueous ethanol Permeation Biochemistry Controlled release Drug permeability General Materials Science Physical and Theoretical Chemistry Biomedical engineering Transdermal media_common
Zdroj:	Journal of Membrane Science. 89:245-255
ISSN:	0376-7388
DOI:	10.1016/0376-7388(94)80106-1
Popis:	A novel biphasic transdermal drug delivery system was developed to provide a technology of varying the temporal rate of the drug input to optimize the chronopharmacological response. The biphasic profile of a drug across skin was obtained by using a permeation enhancer to provide a high initial flux, and a subsequently lower flux by the rapid depletion of the enhancer from a finite volume reservoir. A pseudo-steady-state model was developed to guide the formulation and the design of this system. The performance of a nitroglycerin biphasic transdermal system was demonstrated in vitro, using aqueous ethanol as an enhancer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6c04500a09aa64daa522be3f6d5df392 https://doi.org/10.1016/0376-7388(94)80106-1 Zobrazit plný text záznamu