A New Taraxastane-Type Triterpene fromVitex trifoliavar.simplicifolia
| Autor: | Fei Wang, Ming-Yu Huang, Jie-Ming Xie, Yong-Hong Zhang, Lin-Jing Zhong |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
chemistry.chemical_classification
Traditional medicine biology Chemistry Organic Chemistry biology.organism_classification Biochemistry Catalysis Inorganic Chemistry chemistry.chemical_compound Vitex trifolia Triterpene Betulinic acid Drug Discovery Cerotic acid Casticin Physical and Theoretical Chemistry Cytotoxicity Luteolin Lupeol |
| Zdroj: | Helvetica Chimica Acta. 96:2040-2045 |
| ISSN: | 0018-019X |
| DOI: | 10.1002/hlca.201200614 |
| Popis: | 3-Oxotaraxer-14-en-30-al (1), a new taraxastane-type triterpene, together with 14 known compounds, taraxerone (2), 3-epiursolic acid (3), 2α,3β-dihydroxyurs-12-en-28-oic acid (4), lupeol (5), betulinic acid (6), casticin (7), artemetin (8), luteolin (9), 4-hydroxybenzoic acid (10), docosanoic acid (11), tetracosanoic acid (12), cerotic acid (13), β-sitosterol (14), and β-daucosterol (15), was isolated from the leaves and twigs of Vitex trifolia var. simplicifolia . Compounds 2–6 were found for the first time in this plant. Their structures were established by spectroscopic analysis, including 2D-NMR techniques. Cytotoxic activities of compounds 3, and 5–10 were tested on the three cancer cell lines, PANC-1, K562, and BxPC-3. Results revealed that 7 exhibited cytotoxicity against PANC-1, K562, and BxPC-3, with IC50 values of 4.67, 0.72, and 4.01 μg/ml, respectively, whereas 8 was inactive against these cancer cell lines. The structureactivity relationship of compound 7 and 8 indicated that the 3′-OH group in polymethoxyflavonoids is essential for antitumor activity. |
| Databáze: | OpenAIRE |
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