Anisotropic Crystal Growth Inhibition by Polymeric Additives: Impact on Modulation of Naproxen Crystal Shape and Size
| Autor: | Yin Yani, Reginald B. H. Tan, Vernissa Dilys Chia, Pui Shan Chow, Guangjun Han, Sendhil K. Poornachary |
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| Rok vydání: | 2017 |
| Předmět: |
Supersaturation
Naproxen Polyvinylpyrrolidone technology industry and agriculture 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences 0104 chemical sciences Amorphous solid Crystal chemistry.chemical_compound chemistry Chemical engineering Methyl cellulose medicine Organic chemistry General Materials Science Growth rate 0210 nano-technology Seed crystal medicine.drug |
| Zdroj: | Crystal Growth & Design. 17:4844-4854 |
| ISSN: | 1528-7505 1528-7483 |
| Popis: | This study investigated the effects of polymeric additives such as hydroxypropyl methyl cellulose (HPMC) and polyvinylpyrrolidone (PVP) on the growth kinetics of naproxen crystal, a model poorly water-soluble active pharmaceutical ingredient. These additives are commonly used in pharmaceutical formulations to stabilize fine crystalline suspensions and amorphous solid dispersions. Measurement of seed crystal growth rate in ethanol–water solution as a function of supersaturation suggested a spiral growth mechanism, with the b (needle) axis growth rate five times faster than the c-axis growth rate at 40% relative supersaturation. At nearly equivalent supersaturations, growth along the b-axis was completely inhibited at one end of the seed crystal in the presence of either of the two polymeric additives. In contrast, growth at the other end of the b-axis was significantly accelerated in the presence of PVP. Molecular modeling revealed preferential interaction of the additives with the {011} faces of naproxen ... |
| Databáze: | OpenAIRE |
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