| Autor: | Howard I. Maibach, T. Hartway, Ronald C. Wester, Nicholas Poblete, Julie Christoffel, James Forsell |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Pharmacology
medicine.medical_specialty integumentary system business.industry Organic Chemistry Pharmaceutical Science Human skin Absorption (skin) Cryopreservation Surgery Andrology medicine.anatomical_structure Pharmacokinetics Dermis In vivo medicine Molecular Medicine Pharmacology (medical) business Anaerobic exercise Biotechnology Transdermal |
| Zdroj: | Pharmaceutical Research. 15:82-84 |
| ISSN: | 0724-8741 |
| Popis: | Purpose. For decades, human cadaver skin has been banked and utilized by hospitals for burn wounds and to study percutaneous absorption and transdermal delivery. Skin storage maintenance and confirmation of skin viability is important for both uses, especially for the absorption process where the in vivo situation is simulated. Methods. Our system uses dermatomed human cadaver skin immediately placed in Eagles MEM-BSS, and refrigerated after donor death, then transfered to the laboratory and placed in Eagles MEM-BSS with 50 μg/ml gentamicin at 4°C for storage. Results. Skin viability, determined by anaerobic metabolism where glucose is converted to lactose, was highest (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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