Synthesis of Mono and Bis[60]fullerene-Based Dicationic Peptoids

Autor:	Sreenu Jennepalli, Thomas V. Riley, Stephen G. Pyne, Katherine A. Hammer, Paul A. Keller
Rok vydání:	2014
Předmět:	chemistry.chemical_classification Fullerene Chemistry Stereochemistry Organic Chemistry medicine bacteria Physical and Theoretical Chemistry Template synthesis medicine.disease_cause Escherichia coli Combinatorial chemistry Amino acid
Zdroj:	European Journal of Organic Chemistry. 2015:195-201
ISSN:	1434-193X
DOI:	10.1002/ejoc.201403046
Popis:	Increasing numbers of biological applications of fullerenyl amino acids and their derivatives encouraged us to synthesise [60]fullerenyldihydropyrrole peptides, prepared from the coupling of mono- and bis[60]fullerenyldihydropyrrolecarboxylic acids 4, 5 and 41 with presynthesised peptides 13, 16, 24, 28, 29 and 46. The resulting hydrophobic scaffolded di- and tetra-cationic derivatives were tested against Staphylococcus aureus NCTC 6571 and Escherichia coli NCTC 10418. The synthesis, characterisation and biological results are discussed in this paper.
Databáze:	OpenAIRE
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