Attenuation of pathological spectral theta power by deep brain stimulation in a Parkinson patient

Autor: W. Wedekind, W. Dimpfel
Rok vydání: 2016
Předmět:
Zdroj: Clinical Neurophysiology. 127:e39-e40
ISSN: 1388-2457
DOI: 10.1016/j.clinph.2015.11.125
Popis: A patient (born in 1943) with generalized anxiety since 2008 developed Parkinsonian tremor in 2010. First quantitative EEG recording (neo-CATEEM software using 10/20 electrode positions) was obtained on 10.02.2011. Comparison of spectral power to a norm database of 500 healthy brains revealed enhanced theta power (5–7 Hz) at temporal electrode positions T5 and T6 with a statistical probability of 10000 to 1. This feature was seen under both recording conditions “eyes open” and “eyes closed”. In 11/2012 he got two deep brain electrodes implanted into the nucleus subthalamicus. EEG findings as seen before were reproduced on 22.02.2013 and 24.09.2013. In order to measure the effectiveness of the stimulation further recordings were taken without active stimulation and in the presence of active stimulation on 28.07.2014 and 24.09.2014. During stimulation spectral theta power was attenuated by 50% in comparison to the pre-stimulation recording only at electrode position T6 at both timings (videoclip). The results not only confirm the view that temporal spectral theta power seems to reflect movement problems like tremor but also signalizes that this pathological feature can be influenced successfully by deep brain stimulation. Quantitative EEG recordings might provide a reasonable control for deep brain stimulation in general.
Databáze: OpenAIRE
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