The effect of serial administration of doxorubicin at the level of main female sex hormones in the experiment
| Autor: | I. V. Taran, D. I. Grebeniuk, O. I. Misiurko, V. A. Shamrai |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Reports of Vinnytsia National Medical University. 25:531-534 |
| ISSN: | 2522-9354 1817-7883 |
| DOI: | 10.31393/reports-vnmedical-2021-25(4)-02 |
| Popis: | Annotation. The article presents the results of an experimental study of the dynamics of changes in the main female sex hormones with serial use of doxorubicin. The experiments were performed on 45 adult female white rats. The levels of antimullerian hormone, estradiol and follicle-stimulating hormone were studied. In total, 4 courses of chemotherapy were performed with an interval of 3 weeks. After each course of chemotherapy, the hormonal status of the experimental animals was studied twice: during the first proestrus after the course (to determine the acute ovarian toxicity of the drug) and during the last proestrus before the next course of chemotherapy (to study ovarian function restoration). The obtained data were processed using the statistical software package SPSS 20.0 for Windows. The dynamics of the levels of studied sex hormones with serial administration of doxorubicin is characterized by wavy dynamics with deterioration immediately after chemotherapy and partial recovery during the period between adjacent courses. Ovariotoxicity of doxorubicin when serial administration in therapeutic doses in the experiment is manifested by significant changes in the levels of major female sex hormones after the second course of chemotherapy. |
| Databáze: | OpenAIRE |
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