Integration of reaction and separation in manufacturing of pharmaceuticals: Membrane-mediated production of S-ibuprofen

Autor:	Andrzej Stankiewicz, H. Kierkels, P. Vergossen, V. Cauwenberg
Rok vydání:	1999
Předmět:	Chromatography Membrane reactor Fouling Chemistry Applied Mathematics General Chemical Engineering Ultrafiltration Enantioselective synthesis General Chemistry Ibuprofen Industrial and Manufacturing Engineering Membrane Chemical engineering Long period medicine Inhibitory effect medicine.drug
Zdroj:	Chemical Engineering Science. 54:1473-1477
ISSN:	0009-2509
DOI:	10.1016/s0009-2509(99)00079-2
Popis:	The integration of the reaction and separation in a multifunctional reactor unit for the enantioselective production of S-ibuprofen is studied, both experimentally and by kinetic modeling. The ultrafiltration by a commercially available polyacrylonitril membrane is used for the in-situ removal of the product. The application of the on-line ultrafiltration leads to a twofold increase in the overall productivity, that is due to the decrease of the deactivation and inhibition of the enzyme caused by the product. After initial decrease, probably caused by the fouling, the fluxes through the membrane remain stable for a long period of time. The concept presents a promising option for other systems with conversion limited by the inhibitory effect of the products.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6bd85af4a4ef8234665a6d83c5058afa https://doi.org/10.1016/s0009-2509(99)00079-2 Zobrazit plný text záznamu Full Text from ScienceDirect