A facile method for Rh-catalyzed decarbonylative ortho-C–H alkylation of (hetero)arenes with alkyl carboxylic acids

Autor: Bangyue He, Xiaojie Liu, Yuxi Ren, Yiqiang Tian, Weiping Su
Rok vydání: 2021
Předmět:
Zdroj: RSC Advances. 11:19827-19831
ISSN: 2046-2069
DOI: 10.1039/d1ra03992j
Popis: A facile and effective method for Rh-catalyzed direct ortho-alkylation of C–H bonds in (hetero)arenes with commercially available carboxylic acids has been developed. This strategy was initiated by in situ conversion of carboxylic acids to anhydrides which, without isolation, underwent Rh-catalyzed direct decarbonylative cross-coupling of aryl carboxamides containing 8-aminoquinoline. The reaction proceeds with high regioselectivity and exhibits a broad substrate scope as well as functional group tolerance.
Databáze: OpenAIRE