Myristica Fragrans (Nutmeg) Extract Ameliorated Caffeine-Induced Cardiotoxicity in Male Wistar Rats
| Autor: | Enye Linus Anderson, Saka Olusola Stephen, Sajere Eric Oghenetega, Komolafe Omobola Aderibigbe, Abijo Ayodeji Zabdiel, Ige Mokolade Samson |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Biomedical and Pharmacology Journal. 15:1141-1151 |
| ISSN: | 2456-2610 0974-6242 |
| Popis: | Caffeine is the major constituent found in coffee, tea, energy drinks, and chocolate bar among many others. Several studies have reported various effects of caffeine on the cardiovascular system, although there are inconsistencies in these findings. This study, based on these sought to investigate the role of Myristica fragrans on caffeine-induced cardiotoxicity in male Wistar rats. Twenty-five healthy Wistar rats, weighing 130-135 g were randomly assigned into groups (A-E) n=5 each. Group A received 2 mL/kg distilled water as placebo, group B was administered caffeine (40mg/kg), group C received Myristica fragrans only (200mg/kg), group D received caffeine (40mg/kg), and Myristica fragrans (100mg/kg), while group E received caffeine (40mg/kg) and Myristica fragrans (200mg/kg). The rats were orally-gavaged caffeine and Myristica fragrans with the aid of an oral cannula for 21 days. On the 22nd day after the last administration, rats were euthanized sacrificed and the heart tissues were obtained histological procedures. Percentage weight change was significantly decreased (p |
| Databáze: | OpenAIRE |
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