ChemInform Abstract: 4′-N-Methyl-5′-hydroxystaurosporine and 5′-Hydroxystaurosporine, New Indolocarbazole Alkaloids from a Marine Micromonospora sp. Strain

Autor:	Dolores Garcia Gravalos, Julia Perez Baz, Fernando Espliego Vazquez, Librada M. Canedo Hernandez, José L. Fernández Puentes, Francisco Romero Millan, Jesus Angel de la Fuente Blanco, Rosa Isabel Fernández-Chimeno
Rok vydání:	2001
Předmět:	chemistry.chemical_compound Strain (chemistry) Chemistry Stereochemistry medicine Staurosporine Fermentation Tumor cells General Medicine Indolocarbazole Micromonospora sp medicine.drug 4'-N-methyl-5'-hydroxystaurosporine
Zdroj:	ChemInform. 32
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200105199
Popis:	Two new indolocarbazole alkaloids, 4'-N-methyl-5'-hydroxystaurosporine (2) and 5'-hydroxystaurosporine (3), were isolated together with the known staurosporine (1) from the culture broth of a marine Micromonospora sp. (strain L-31-CLCO-002). The fermentation, structural data and cytotoxic activities of these compounds against various tumor cell lines are given.
Databáze:	OpenAIRE
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