Antibacterial and antifungal activities of indican (indoxyl -D-glucoside)
| Autor: | Edeltrudes de Oliveira Lima, Sã nia Pereira Leite, Ivanise Brito da Silva, Roberta Maria de Leite Lima, Izabela Lima Rangel, Paloma Lys de Medeiros |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pharmacology biology 030106 microbiology Broth microdilution Pharmaceutical Science Indican biology.organism_classification Microbiology Candida tropicalis 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology chemistry Indoxyl Staphylococcus epidermidis Candida krusei Antibacterial activity Candida albicans |
| Zdroj: | African Journal of Pharmacy and Pharmacology. 10:200-205 |
| ISSN: | 1996-0816 |
| Popis: | Indican (Indoxyl β-d-glucoside), plant pigments found in true Indigo, are present in Indigofera genus plants, fungi and human urine. This study evaluated the antibacterial and antifungal activities of this pigment using the microdilution method. Antibacterial and antifungal activities were performed against Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, Candida albicans, Candida tropicalis, Candida krusei, Trichophyton rubrum, Trichophyton mentagrophytes and Microsporum gypseun. Minimum inhibitory concentrations (MICs) were measured according to the broth microdilution protocols by the Clinical and Laboratory Standards Institute (CLSI). The Indican showed only antifungal activity. It had MIC values of 128 µg/mL for yeasts and 512 µg/mL for most of the dermatophytes. The minimum fungicidal concentration (MFC) values of the Indican ranged between 512 μg/mL: C. tropicalis (LM-6) and C. krusei (LM-6 and LM-8) and 1,024 μg/mL: C. albicans (ATCC-76645, LM-108, LM-P20). Further studies are needed to clarify the potential fungicidal activity of the Indican and the possibility for topical applications. Key words: Antibacterial activity, antifungal activity, indican. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|