Dehydrogenase Activity in the Brain of Fluoride and Aluminium Induced Wistar Rats
| Autor: | Memudu Ae, Akinrinade Id, B. J. Dare, Olalekan M. Ogundele |
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| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_classification
History Excitotoxicity Dehydrogenase Biology medicine.disease_cause Computer Science Applications Education chemistry.chemical_compound Enzyme chemistry Biochemistry Lactate dehydrogenase Sodium fluoride medicine Glucose-6-phosphate dehydrogenase Fluoride Oxidative stress |
| Zdroj: | Biological Systems: Open Access. |
| ISSN: | 2329-6577 |
| Popis: | Dehydrogenases are cellular enzymes usually used as indicators of changes in cell activity and morphology; this includes metabolic processes such as structural differentiation, cell migration, cellular damage and even cell death; hence, assay of enzymes as Lactate dehydrogenase and Glucose 6 phosphate dehydrogenase could provide evidence for the role of some compounds in the stimulation of oxidative stress, cellular damage and eventually cell death. In this study, examination of Lactate dehydrogenase and Glucose 6 phosphate dehydrogenase in the Prefrontal cortex of Aluminium and Fluoride induced wistar rats was done by administering sodium fluoride (10 mg/kg) and Aluminium Chloride (200 mg/kg). The study employed assay of glucose-6-phospahte dehydrogenase (G6PDH) and lactate dehydrogenase (LDH) levels to determine possible oxidative stress and cellular damage. Results showed alterations in the enzyme levels of G6PDH and LDH indicating a high level of dehydrogenase activity in the treatment groups. This shows that Fluoride and Aluminium have a high potential of causing excitotoxicity, oxidative stress and eventually cellular damage. |
| Databáze: | OpenAIRE |
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