Interactions Between LHRH, Sex Steroids and 'Inhibin' in the Control of LH and FSH Secretion
| Autor: | Jacques Drouin, L. Ferland, Jocelyne Massicotte, Lisette Lagacé, Claude Bonne, Fernand Labrie, Jean-Pierre Raynaud, Jennifer H. Dorrington, Paul A. Kelly |
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| Rok vydání: | 1978 |
| Předmět: |
endocrine system
medicine.medical_specialty medicine.drug_class Chemistry Urology Endocrinology Diabetes and Metabolism Inhibitory postsynaptic potential Sertoli cell In vitro Gonadotropin secretion FSH secretion Andrology medicine.anatomical_structure Endocrinology Reproductive Medicine Anterior pituitary In vivo Internal medicine medicine Gonadotropin hormones hormone substitutes and hormone antagonists |
| Zdroj: | International Journal of Andrology. 1:81-101 |
| ISSN: | 1365-2605 0105-6263 |
| DOI: | 10.1111/j.1365-2605.1978.tb00008.x |
| Popis: | Using anterior pituitary cells obtained from adult male rats, 17β-estradiol stimulated both spontaneous and LHRH-induced LH and FSH secretion. After in vivo administration, estrogens showed inhibitory or stimulatory effects on gonadotropin secretion, the effect being dose- and time-dependent. Contrary to estrogens, androgens had differential effects at the anterior pituitary level: they inhibited LH but stimulated FSH secretion. These in vitro data were confirmed by in vivo experiments using anti-androgens. Sertoli cell culture medium was found to be a potent inhibitor of spontaneous FSH secretion while no effect was detected on LH release. When the gonadotropin response to LHRH was studied, Sertoli cell culture medium was a more potent inhibitor of FSH than LH release although clear inhibition of LHRH-induced LH release did occur. |
| Databáze: | OpenAIRE |
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