A novel synthesis of didehydroamino acid esters from azomethine ylides

Autor:	Miklos Nyerges, Andrea Arany, David E. Hibbs, Toqir Sharif, Ian Garnett, Paul W. Groundwater, Michael B. Hursthouse
Rok vydání:	1998
Předmět:	chemistry.chemical_classification Aldimine chemistry.chemical_compound Chemistry Imidazolidine Imine Organic chemistry Azomethine ylide Medicinal chemistry Cycloaddition
Zdroj:	Journal of the Chemical Society, Perkin Transactions 1. :2837-2846
ISSN:	1364-5463 0300-922X
Popis:	A novel synthesis of didehydroamino acid (DDAA) esters 5 is described, starting from aldimines 2. The mechanism for this reaction has been shown to involve the cycloaddition of an azomethine ylide 3 to an imine 2, followed by the base-catalysed ring-opening of the resulting imidazolidine intermediate 7. This novel method has also been extended to the synthesis of DDAA esters 5 catalysed by imines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6bb9ca1ac1e5e8b73ff180f4670a88ef https://doi.org/10.1039/a803695k Zobrazit plný text záznamu