Comparison of Results for Three Methods of Hemoglobin S Identification

Autor:	John A. Griep, Edward J. Hicks, Carleton D. Nordschow
Rok vydání:	1973
Předmět:	Hemoglobin s chemistry.chemical_compound Chromatography chemistry Biochemistry (medical) Clinical Biochemistry False Negative Reactions Reduction test Hemoglobin Cellulose acetate electrophoresis Dithionite Cellulose acetate Mass screening
Zdroj:	Clinical Chemistry. 19:533-535
ISSN:	1530-8561 0009-9147
DOI:	10.1093/clinchem/19.5.533
Popis:	We present comparative results of three diagnostic tests for identification of hemoglobin S, performed on specimens from a total of 4,739 persons. A simple, rapid, and economical procedure for cellulose acetate electrophoresis was more efficient than either the "Sickledex" test (a dithionite test) or the metabisulfite reduction test. This is an important consideration as a minimum requirement for effective therapy and genetic counseling. We propose electrophoresis of hemoglobin on cellulose acetate as a primary screening procedure—with verification of positive samples by solubility tests—and discuss its feasibility.
Databáze:	OpenAIRE
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