Synthesis and X-ray crystallographic analysis of chiral pyridyl substituted carbocyclic molecular clefts

Autor:	Louis M. Rendina, Connie K. Y. Lee, Margaret M. Harding, Peter Turner, Jennifer L. Groneman
Rok vydání:	2006
Předmět:	chemistry.chemical_classification Stereochemistry Organic Chemistry Supramolecular chemistry Alkyne chemistry.chemical_element Aromaticity Nuclear magnetic resonance spectroscopy Biochemistry Coupling reaction Crystallography chemistry Drug Discovery Molecule Chirality (chemistry) Palladium
Zdroj:	Tetrahedron. 62:4870-4878
ISSN:	0040-4020
DOI:	10.1016/j.tet.2006.03.014
Popis:	Ditopic symmetrical bis(pyridyl) ligands incorporating the chiral dibenzobicyclo[b,f][3.3.1]nona-5a,6a-diene-6,12-dione cleft have been synthesised and characterised by NMR spectroscopy, mass spectrometry and X-ray crystallography. The ligands, which incorporate pyridyl groups directly connected to the carbocyclic cleft core or via alkyne or phenyl linkers were accessed from palladium-catalysed coupling reactions of 2,8-dibromodibenzobicyclo[b,f][3.3.1]nona-5a,6a-diene-6,12-dione. X-ray crystal analyses show the interplanar angles between the two cleft aromatic rings in these molecules, which range from 97.80(3) to 109.80(4)°.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6ba97d1aee7b68c9a66a5a5b77d7dc7d https://doi.org/10.1016/j.tet.2006.03.014 Zobrazit plný text záznamu Full Text from ScienceDirect