| Popis: |
As reported earlier, deoxycytidine (dC) antagonizes the effect of a natural growth inhibitor, isolated from bovine mammary gland, on mouse Ehrlich ascites carcinoma cells in the same way as the polypeptide growth factors insulin and epidermal growth-factor (EGF) do [6]. Bhalla et al. [1] found that this nucleoside is able to overcome the inhibitory effect of acidic isoferritin, prostaglandin E1 and leukemia inhibitory factor on colony-forming unit-granulocyte macrophage (CFU-GM). Moreover, these authors found that dC stimulates the growth of CFU-GM. We demonstrated [8] that dC antagonizes the effect of the hemoregulatory pentapeptide, described by Kreja et al. [3], and of an inhibitor of colony-forming unit-spleen (CFU-S), described by Lord et al. [7]. Again, dC effects were identical to those of insulin and EGF in these systems. |
