Correction for arterial-tissue delay and dispersion in absolute quantitative cerebral perfusion DSC MR imaging
| Autor: | Bernard R. Bendok, Michael C. Hurley, Colin P. Derdeyn, Wanyong Shin, Sameer A. Ansari, Jessy J. Mouannes-Srour, Timothy J. Carroll, Parmede Vakil, John L. Lee |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry Cerebral arteries Pulse sequence Mr imaging Magnetic resonance angiography Cerebral blood flow Positron emission tomography medicine Radiology Nuclear Medicine and imaging Radiology Deconvolution Cerebral perfusion pressure Nuclear medicine business |
| Zdroj: | Magnetic Resonance in Medicine. 68:495-506 |
| ISSN: | 0740-3194 |
| DOI: | 10.1002/mrm.23257 |
| Popis: | The singular value decomposition deconvolution of cerebral tissue concentration-time (C-T) curves with the arterial input function (AIF) is commonly used in dynamic susceptibility contrast (DSC) cerebral perfusion MR imaging. However, it is sensitive to the time discrepancy between the arrival of the bolus in the tissue C-T curve and the AIF signal. This normally causes inaccuracy in the quantitative perfusion maps due to delay and dispersion effects. A comprehensive correction algorithm has been achieved through slice-dependent time-shifting of the AIF, and a delay-dependent dispersion correction model. The correction algorithm was tested in 11 healthy subjects and 3 ischemic stroke patients scanned with a quantitative perfusion pulse sequence at 1.5T. A validation study was performed on 5 patients with confirmed cerebrovascular occlusive disease scanned with MRI and positron emission tomography (PET) at 3.0T. A significant effect (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text