| Autor: |
R. Renoux, E. Beyssac, Jean-Marc Aiache, J.-P. Kantelip, S. Aiache, M. Islasse |
| Rok vydání: |
1987 |
| Předmět: |
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| Zdroj: |
International Journal of Pharmaceutics. 39:235-242 |
| ISSN: |
0378-5173 |
| DOI: |
10.1016/0378-5173(87)90221-3 |
| Popis: |
The ‘in vitro’ dissolution kinetics of two suppository formulations containing indomethacin were compared and a correlation with the ‘in vitro’ kinetics was established. The device used ‘in vitro’ was a special through flow cell. A mean dissolution curve was obtained for each dosage form, one containing a hydrophilic excipient (PEG), the other, a fatty base. A relative bioavailability study was then carried out on 12 healthy volunteers. Thus, from the pharmacokinetic parameters obtained, the simulation of plasma concentration values was made possible from the amounts of drug released and dissolved during the dissolution test. With the simulation programme used it was possible to predict the plasma level values and the results showed a good superimposition of the experimental plasma concentration curve validating the ‘in vitro’ study method of drug release from suppositories. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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