Effect of avitaminosis B6 in mice on T-lymphocyte function in vitro
| Autor: | A. V. Sergeev, M. O. Raushenbakh, A. A. Ivanov, L. M. Luchanskaya, S. N. Bykovskaya |
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| Rok vydání: | 1977 |
| Předmět: |
medicine.medical_specialty
Lysis Spleen General Medicine T lymphocyte Biology Pyridoxine General Biochemistry Genetics and Molecular Biology In vitro Cytolysis chemistry.chemical_compound medicine.anatomical_structure Endocrinology chemistry Internal medicine Immunology medicine Thymidine Pyridoxal medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 84:1139-1142 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | The effect of different degrees of avitaminosis B6 in mice on the cytolytic activity of T lymphocytes, measured as the quantity of Na2Cr51O4 released from lysed target cells, was studied on a model of the primary immune response in a mixed lymphocyte culture in vitro. Keeping animals for 3 weeks on a diet without pyridoxine did not affect the ability of the lymphocytes to proliferate in vitro or their cytolytic activity. In animals receiving a diet without pyridoxine for 45 days the content of pyridoxal-5′-phosphate in the spleen was 55% lower than in the control. Lymphocytes taken from these animals, when cultured in vitro, showed sharply weakened ability to incorporate [3H]thymidine into DNA in response to the alloantigen. The cytolytic activity of these lymphocytes also was reduced. The ability of different forms of pyridoxine to restore the functions of T lymphocytes, when disturbed by avitaminosis B6, was studied. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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