Different response criteria to cardiac resynchronization therapy in patients with congestive heart failure
| Autor: | A. M. Soldatova, V. A. Kuznetsov, D. S. Malishevskaya, L. M. Malishevskii, T. N. Enina, E. A. Gorbatenko |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Journal of Arrhythmology. 29:21-28 |
| ISSN: | 2658-7327 1561-8641 |
| DOI: | 10.35336/va-2022-3-03 |
| Popis: | Aim. To investigate the agreement among different response criteria to cardiac resynchronization therapy (CRT) and long-term mortality in patients with congestive heart failure (CHF).Methods. The study enrolled 141 patients (men 77.3%; women 22.7%) with CHF (65.2% ischemic and 34.8% non-ischemic etiology). Mean age was 58.6 [53.0;66.0] years. All patients had NYHA II-IV, left ventricular ejection fraction (LVEF) ≤35%; QRS ≥130 мs and/or left bundle branch block. Mean follow-up period was 45.0±34.2 months. Response to CRT was defined according to dynamics of NYHA functional class, LVEF, and left-ventricular end-systolic volume (LVESV).Results. Moderate agreement was found among LVEF and LVESV (Cohen’s k coefficient 0.591±0.068) while we did not find the agreement among echocardiographic criteria and NYHA. Long-term mortality had moderate negative correlation with LVESV (r=-0.486; pConclusion. Agreement between different criteria to define response to CRT is poor. The strongest correlation with long-term mortality was found for LVESV. This inconsistency among different response criteria severely limits the ability to generalize results over multiple CRT studies. |
| Databáze: | OpenAIRE |
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