Biodegradable collagen matrix implant for trabeculectomy
| Autor: | Joseph R Zelefsky, Wei-Cherng Hsu, Robert Ritch |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Scaffold
medicine.medical_specialty business.industry medicine.medical_treatment Biomedical Engineering Glaucoma Connective tissue medicine.disease Surgery Ophthalmology Increased risk medicine.anatomical_structure Glaucoma surgery Medicine Trabeculectomy Implant business Optometry Biomedical engineering Scleral flap |
| Zdroj: | Expert Review of Ophthalmology. 3:613-617 |
| ISSN: | 1746-9902 1746-9899 |
| Popis: | The biodegradable collagen matrix implant, marketed initially as OculusGen™ and currently as Ologen™ and iGen™, is a novel bioengineered implant designed to be used at the time of trabeculectomy. It consists of a collagen-based scaffold containing thousands of microscopic pores. The implant is placed directly over the scleral flap and influences the healing process by forcing fibroblasts and myofibroblasts to grow into the pores and secrete connective tissue in the form of a loose matrix. This results in decreased scar formation and improved surgical success over trabeculectomy performed without the adjunctive use of antifibrotic agents. Preliminary studies have demonstrated that the biodegradable collagen matrix is effective for use in trabeculectomy, although it may be associated with an increased risk of early postoperative hypotony. Future randomized, controlled trials should help determine its place in glaucoma surgery. |
| Databáze: | OpenAIRE |
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