Anemia and iron biomarkers in patients with early breast cancer. Diagnostic value of hepcidin and soluble transferrin receptor quantification1)
| Autor: | Marian Gutowski, Simon Thezenas, Anna Durigova, Pierre-Jean Lamy, William Jacot, Stéphane Pouderoux, Frédéric Montels, Gilles Romieu |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Chemotherapy biology business.industry Anemia medicine.medical_treatment Biochemistry (medical) Clinical Biochemistry Cancer General Medicine Iron deficiency medicine.disease Gastroenterology Breast cancer Hepcidin hemic and lymphatic diseases Internal medicine Immunology medicine biology.protein Hemoglobin business Soluble transferrin receptor |
| Zdroj: | Clinical Chemistry and Laboratory Medicine. 51 |
| ISSN: | 1437-4331 1434-6621 |
| Popis: | Background: Anemia, a frequent and deleterious condi tion in patients with cancer, is mainly caused by chemo therapy toxicity, iron deficiency, or inflammation. We evaluated the baseline iron metabolism biomarkers and their association with anemia occurrence during chemo therapy in patients with early breast cancer (EBC). Methods: In this monocentric retrospective study, clas sical iron metabolism markers and new biomarkers as well as sTfR and hepcidin were assessed at baseline in 347 patients with EBC who received a sequential taxane and anthracyclinebased regimen between April 2007 and October 2009. Hemoglobin level was measured every 21 days. Results: Thirtyfive patients had baseline iron deficiency and 13 inflammatory iron sequestration. In multivariate analysis, only high sTfR (OR = 27.6, p < 0.001, 95% CI 8.74– 87) and premenopausal status (OR = 7.3, 95% CI 0.04–0.43, p = 0.001) remained statistically associated with iron deficiency. High hepcidin values and inflammatory iron sequestration were significantly associated (p = 0.032). In total 6.1% patients had baseline anemia and 86.2% patients developed anemia during chemotherapy (41 had grade ≥ 2 anemia). Baseline hemoglobin below 13 g/dL and low hepcidin levels were the two independent predic tive factors of severe anemia. Conclusions: In early breast cancer treated by chemo therapy, only baseline hemoglobin and hepcidin levels are independent predictive factors of anemic syndrome occurrence. |
| Databáze: | OpenAIRE |
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