Hemovigilance survey of pathogen-reduced blood components in the Warsaw Region in the 2009 to 2013 period
| Autor: | Aleksandra Rosiek, Magdalena Łętowska, Lech Rzymkiewicz, Elżbieta Lachert, Zofia Przybylska, Dariusz Piotrowski, Marcia da Silva Cardoso |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Hemovigilance Acquired Thrombotic Thrombocytopenic Purpura Blood transfusion Hematology business.industry medicine.medical_treatment Immunology Transfusion medicine Retrospective cohort study 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Immunology and Allergy Platelet Adverse effect business 030215 immunology |
| Zdroj: | Transfusion. 56:S39-S44 |
| ISSN: | 0041-1132 |
| DOI: | 10.1111/trf.13330 |
| Popis: | Background In 2009 the Mirasol Pathogen Reduction Technology (PRT) was introduced to the routine blood component production of the Regional Blood Transfusion Center in Warsaw (RBTCW). The goal of this study was to investigate the safety of Mirasol-treated blood components. Study design and methods The accumulated passive hemovigilance data of Mirasol-treated blood components collected at the RBTCW are presented and compared to historical and contemporary data. Furthermore, active hemovigilance data collected from patients with different hematologic disorders transfused with Mirasol-treated or untreated blood components at the Institute of Hematology and Transfusion Medicine (IHTM) are presented and discussed. Results The adverse reaction (AR) reporting rate by hospitals to the RBTCW after the implementation of the Mirasol technology was 0.39% for Mirasol-treated platelet concentrates (M-PCs) and 0.05% for Mirasol-treated fresh-frozen plasma. When comparing contemporary rates of ARs recorded by RBTCW in the time period 2011 to 2012, no statistical difference was observed between Mirasol-treated and untreated blood components. No serious AR was attributed to Mirasol-treated components. At the IHTM a lower rate of ARs after transfusion of M-PCs was observed than with untreated PCs. Despite the fact that very large amounts of Mirasol-treated plasma have been transfused to patients with congenital or acquired thrombotic thrombocytopenic purpura, no significant increase in AR rates was observed. Conclusion Treatment of blood components with the Mirasol PRT System has proven to be safe for patients and is not associated with increased rates and grades of adverse events in patients of hospitals in the Warsaw Region. |
| Databáze: | OpenAIRE |
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