Effect of Date Fruits, Phoenix Dactyliferia L., on the Hemolytic Activity of Streptolysin O
| Autor: | Nizar Mohammad Abuharfeil, Saeb El. Sukhon, Abdul-Karim J. Sallal, Yousef Msameh |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Pharmacology
Pharmaceutical Science General Medicine Biology medicine.disease_cause medicine.disease Hemolysis Microbiology Titer Complementary and alternative medicine Drug Discovery Streptococcus pyogenes Phoenix dactylifera medicine Molecular Medicine Streptolysin Incubation Exotoxin Antibacterial agent |
| Zdroj: | Pharmaceutical Biology. 37:335-339 |
| ISSN: | 1744-5116 1388-0209 |
| Popis: | The effect of date fruit Phoenix dactylifera (Arecacaea) extracts on Streptococcus pyogenes was examined in vivo and in vitro. It was found that incubation for 24 h with date fruit extract at 5, 10 and 20% dilution effectively slowed the growth of S. pyogenes to 30.8, 64.7 and 88.5%, respectively. Date extract (DE) neutralized the hemolytic activity of the streptococcal exotoxin, streptolysin O, at very low concentrations. Inhibition of 96% was obtained at 1:262144 DE dilution. The inhibitory substance was found to be steroidal in nature and not proteinaceous as deproteinization of DE did not decrease its inhibitory effect. The results indicated that the neutralization property of this factor is most probably due to erythrocyte membrane stabilization and inhibition of streptolysin O enzyme. Date intake did not affect the titer of antistreptolysin O antibodies. |
| Databáze: | OpenAIRE |
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