Niraparib with Abiraterone Acetate and Prednisone for Metastatic Castration-Resistant Prostate Cancer: Phase II QUEST Study Results

Autor:	Kim N Chi, Neil Fleshner, Vincenzo Emanuele Chiuri, Siska Van Bruwaene, Jason Hafron, Douglas G McNeel, Peter De Porre, Raymond Scott Maul, Mahesh Daksh, Xiaogang Zhong, Gary E Mason, Ronald F Tutrone
Rok vydání:	2023
Předmět:	Cancer Research Oncology
Zdroj:	The Oncologist. 28:e309-e312
ISSN:	1549-490X 1083-7159
Popis:	Niraparib (NIRA) is a highly selective inhibitor of poly (adenosine diphosphate-ribose) polymerase, PARP1 and PARP2, which play a role in DNA repair. The phase II QUEST study evaluated NIRA combinations in patients with metastatic castration-resistant prostate cancer who were positive for homologous recombination repair gene alterations and had progressed on 1 prior line of novel androgen receptor-targeted therapy. Results from the combination of NIRA with abiraterone acetate plus prednisone, which disrupts androgen axis signaling through inhibition of CYP17, showed promising efficacy and a manageable safety profile in this patient population.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6b689a1fdfe304041fa31fc2b670b965 https://doi.org/10.1093/oncolo/oyad008 Zobrazit plný text záznamu