Low plasma progestin concentration during the early postovulatory phase impairs equine conceptus development in the late preimplantation phase
| Autor: | Camille Gautier, Christine Aurich, D. Scarlet, Martim Kaps, Carolina T. C. Okada, Joerg Aurich, Stephan Handschuh, Maria Melchert |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.drug_class
media_common.quotation_subject Uterus Prostaglandin Reproductive technology Biology Andrology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Genetics medicine Conceptus Molecular Biology Ovulation reproductive and urinary physiology 030304 developmental biology media_common 0303 health sciences 030219 obstetrics & reproductive medicine urogenital system Placentation Embryo medicine.anatomical_structure Reproductive Medicine chemistry embryonic structures Animal Science and Zoology Progestin Developmental Biology Biotechnology |
| Zdroj: | Reproduction, Fertility and Development. |
| ISSN: | 1031-3613 |
| DOI: | 10.1071/rd20116 |
| Popis: | In horses, low postovulatory progestin concentrations delay downregulation of endometrial progesterone receptors, impairing histotroph composition. The aim of this study was to evaluate conceptus development until placentation in mares under experimentally reduced progestin concentrations in the early postovulatory phase. Eleven mares were inseminated until ovulation and received the prostaglandin F2α agonist cloprostenol (125 µg) once daily for 4 days after ovulation (treatment) or were left untreated (control). Conceptus growth and development was analysed daily from Day 10 after ovulation by ultrasound. On Day 34 conceptuses were recovered and underwent microcomputed tomography. Statistical comparison was performed by non-parametric Wilcoxon test or Chi2. First visualisation of embryonic vesicle, embryo proper and heartbeat did not differ. Conceptus fixation in the uterus occurred earlier in controls than in conceptuses recovered from treatment pregnancies (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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