A model of acute hepatic failure in rabbits

Autor: E. S. Ketiladze, L. G. Erokhina, V. S. Kondrat'ev, G. T. Chernenko, L. V. Gubskii, R. T. Toguzov, V. V. Mit'kin, D. M. Braginskii, L. F. Peganova, N. A. Farber
Rok vydání: 1982
Předmět:
Zdroj: Bulletin of Experimental Biology and Medicine. 93:742-746
ISSN: 1573-8221
0007-4888
Popis: Definite progress has been made in recent studies of the pathogenesis of viral hepatitis [2, 5-7]. However, many practical problems connected with the treatment of severe forms of viral hepatitis B (HB), especially if complicated by acute hepatic failure (AHF), still remain unsolved. An adequate experimental model is necessary to study some aspects of this problem. However, the development of such a model is associated with objective difficulties, including the existence of human carriers of HB virus and the insufficient comparability of forms of virus hepatitis found in animals, notably virus hepatitis of mice [i, 7, i0], and HB in man. Attempts to create an analog of HB by administration of carbon tetrachloride to animals have also proved unsuitable because the process it causes in the liver is one of fatty infiltration rather than necrobiosis. In 1978, a model of AHF closely resembling the disease in man was produced for the first time in rabbits with aid of the selective hepatotoxin D-galactosamine (DGA) [i0].
Databáze: OpenAIRE
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