Simultaneous Estimation of Paracetamol, Chlorzoxazone and Ibuprofen by Validated Spectrophotometric Methods
Autor: | Nilima S. Pawar, Ramesh L. Sawant, Rupali Joshi, Pandurang Gaikwad |
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Rok vydání: | 2012 |
Předmět: | |
Zdroj: | Analytical Chemistry Letters. 2:118-124 |
ISSN: | 2230-7532 2229-7928 |
DOI: | 10.1080/222979282000.10648258 |
Popis: | Shimadzu UV 1700 was used for quantitation. Method I is three wavelength spectroscopy where absorbance of the sample solution was measured at 287.2 nm and 295.2 nm for the determination of paracetamol, chlorzoxazone, and at 221.8 nm for ibuprofen, respectively. Method II is multiwavelength spectroscopy where absorbance of standard solutions was measured at 221.8 nm, 256 nm, 287.2 nm and 295.2 nm and result of the sample solution obtained by statistical calculations. Beer’s law limit was 0–40 μg/ml for paracetamol and chlorzoxazone where as 0–25 μg/ml for ibuprofen. Validation study was found statistically significant. The LOD values were 0.4217, 0.0658 and 0.1245 μg/mL whereas LOQ values were 1.3457, 0.5874 and 0.4512 μg/mL for paracetamol, chlorzoxazone and ibuprofen respectively. Low % RSD and high recovery shows the dependability of the method for quantitation of drugs in tablet formulation. The developed methods are easy, rapid, economic and accurate for regular simultaneous estimation of par... |
Databáze: | OpenAIRE |
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