| Popis: |
Free radical injury to cremater muscle and pial venules was studied by intravital videomicroscopy. Insult was induced by photoactivation (mercury light, 25 lm/cm 2 at 570 nm) of intravascular rose bengal. The protective effects of flunarizine (25, 100 and 400 μ g/kg, i.v.) vs. its cyclodextrine solvent (100 mg/kg) and isovolemic saline (control) were assessed. Observations at 30 min postinsult showed that the flunarizine-treated groups had higher cremaster venular patency rates than the control group ( P μ g/kg flunarizine-treated group had a significantly higher ( P P μ g/kg, i.v.) pretreatment than without. This study characterizes the nature and time-course of free-radical-induced microvascular damage and demonstrates the protective action of flunarizine. |
