Protective Effects Of Tecomella Undulata Stem Bark Extract On Isoniazid Induced Hepatotoxicity: Based On Liver Enzymes And Histopathology In Rat Model
| Autor: | M. Ashraf, Syed Ijaz Hussain Zaidi, Shabih Zehra, Abdul Lateef Mahesar, Zubaida Umar Zehri, M. Anwar |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
biology medicine.diagnostic_test Tecomella undulata Bilirubin business.industry Isoniazid Pharmacology biology.organism_classification Group B chemistry.chemical_compound chemistry Oral administration Toxicity medicine Histopathology Liver function tests business medicine.drug |
| Zdroj: | Journal of Bahria University Medical and Dental College. 10:49-52 |
| ISSN: | 2617-9482 2220-7562 |
| DOI: | 10.51985/jbumdc2019124 |
| Popis: | Objective: To evaluate the hepatoprotective effects of Tecomellaundulata stem bark extract on isoniazid induced hepatic damage based on liver enzymes and Liver function test in rat models. Study design and Setting: An experimental study conducted at Department of Pharmacology at Al-Tibri Medical College and Hospital, Isra University Karachi Campus and Dow University of Health Sciences, Karachi. Methodology: Total twenty-four rats were studied. The albino rats that were male, healthy, and weighing 200-250grams were included in this study. Rats were divided into four groups, each group having six rats and treated once daily orally for 30 days. Group A was control group and treated with normal animal diet and water; Group B was Isoniazid treated group and induced by oral administration of Isoniazid (INH) 50mg/kg. Group C was treated with Isoniazid 50mg/kg and Tecomellaundulata bark extract with low dose of 200mg/kg . Group D was treated with Isoniazid 50mg/kg and Tecomellaundulata bark extract with high dose of 400mg/kg . All the animals were weighed before commencement of the study. Liver enzymes were noted after the end of experiment. P value of |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|