Effects of 17β-Estradiol on Dopamine D2 Receptors in Thiamine-Deficient Female Rats: Consequences on Sucrose, Alcohol, Water Intakes and Body Weight

Autor:	Abdoulaye B acirc, Seydou Silué
Rok vydání:	2019
Předmět:	medicine.medical_specialty Sucrose Alcohol Bromocriptine Mesylate chemistry.chemical_compound Endocrinology chemistry Internal medicine Dopamine receptor D2 medicine Thiamine medicine.symptom Receptor Sulpiride Weight gain medicine.drug
Zdroj:	Journal of Biosciences and Medicines. :36-55
ISSN:	2327-509X 2327-5081
Popis:	Our previous studies showed that 17β-estradiol (E2) modulated dopamine D2 receptor in regulating body weight set-point. The aim of this study was to understand whether thiamine deficiency influenced the E2 modulation on dopamine D2 receptors, using bromocriptine mesylate (BR) and sulpiride (SUL) as selective central dopamine-D2 receptors agonist and antagonist respectively. We studied the E2-dopamine D2 receptors interferences in a 10-day thiamine-deficient female rats for which consumptions of water, sugar, alcohol and food were daily-recorded and their consequences on body weights assessed. Our results showed that the volume of water daily ingested doubled in thiamine-deficient female rats (OXT), while sugar and alcohol consumptions collapsed with decreased weight and food consumption. On the one hand, thiamine potentiated D2/BR activity (bromocriptine-activated D2 receptors) to induce sugar intake and inhibited the same D2/BR receptors to induce water intake. On the other hand, thiamine promoted D2/SUL receptors (sulpiride-inhibited D2 receptors) for enhanced alcohol intake, increased food consumption and weight gain. Taking together, thiamine modulated the actions of 17β-estradiol on both D2/BR and D2/SUL receptors activities.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6b1b665feb92ce2405aec1ebe57571be https://doi.org/10.4236/jbm.2019.711004 Zobrazit plný text záznamu