Aberrant Methylation of 21 MicroRNA Genes in Breast Cancer: Sets of Genes Associated with Progression and a System of Markers for Predicting Metastasis

Autor:	Eleonora A. Braga, S S Lukina, D. S. Khodyrev, A. M. Burdennyy, A. V. Karpukhin, Vitaly I. Loginov, I. V. Pronina, E. A. Filippova, Tatiana P. Kazubskaya
Rok vydání:	2021
Předmět:	Aberrant methylation General Medicine Methylation Lymph node metastasis Biology medicine.disease General Biochemistry Genetics and Molecular Biology Metastasis Breast cancer DNA methylation microRNA Cancer research medicine Gene
Zdroj:	Bulletin of Experimental Biology and Medicine. 172:67-71
ISSN:	1573-8221 0007-4888
DOI:	10.1007/s10517-021-05333-x
Popis:	Systemic analysis of the relationship between the levels of methylation of 21 microRNA genes and the parameters of breast cancer progression was performed on a representative sample of 91 paired specimens of breast cancer and histologically normal tissues and a system of markers for prediction of metastasis was proposed. A significant association of hypermethylation of 11 genes with late (III-IV) clinical stages was found, and for 6 genes (MIR124-1, MIR127, MIR34B/C, MIR9-3, MIR1258, and MIR339) this association was highly significant (p≤0.001, FDR=0.01). For MIR9-3 and MIR339, an association with tumor size was demonstrated (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6b177a9bb20f9d691f1ac875c6c5f846 https://doi.org/10.1007/s10517-021-05333-x Zobrazit plný text záznamu Full text from SpringerLink