RETARDING EFFECT OF SIMVASTATIN ON ARTERY REMODELLING INDUCED BY HIGH-SALT AND HIGH-FAT DIET IN RATS
| Autor: | Ye yongwei, Huang haozhang, Wen Han-chun, Guan qinglin, Huang lushuang, Zhu Ji-jin, Yin mingjing |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
CD40 biology business.industry H&E stain High fat diet Endocrinology Blood pressure medicine.anatomical_structure Simvastatin Internal medicine medicine.artery Ascending aorta medicine biology.protein Immunohistochemistry Cardiology and Cardiovascular Medicine business Artery medicine.drug |
| Zdroj: | Heart. 98:E55.1-E55 |
| ISSN: | 1468-201X 1355-6037 |
| DOI: | 10.1136/heartjnl-2012-302920a.135 |
| Popis: | Objectives To investigate the effect of simvastatin intervention on the changes of blood pressure, serum lipid fluctuation and aortic configuration induced by high sodium plus high fat diets in rats. Methods Sixty adult male SD rats were randomly divided into five groups (n=12); control group (N), high salt group (S), high fat group (F), high salt+high fat group (SF) and high salt plus high fat+simvastatin group (T). After fed for 16 weeks, the rats were subject to determine blood pressures and serum concentrations of TC, TG and sCD40L. The expression of CD40/CD40L in the root of ascending aorta was detected by immunohistochemical method. The thickness of intima media in the ascending aorta as well as the ratio of lumen area/total vascular area were measured and calculated after HE staining. Results In S group, F group and SF group, systolic blood pressure was significantly higher than that in N group (p Conclusions Feeding high fat plus high salt leads to blood pressure elevation, induces atherosclerosis, increases serum concentrations of sCD40L and enhances the expression of CD40/CD40L in arterial tissues. The combination of stimulus has stronger effect than a single factor. Statins protect the arterial tissues against atherosclerosis by decreasing the level of serum sCD40L and inhibiting the expression of arterial tissues CD40/CD40L. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|