Modulation of immune function occurs within hours of therapy initiation for multiple sclerosis (P5189)
| Autor: | Sushmita Sinha, Chris Ayers, Jason Mendoza, Khrishen Cunnusamy, Benjamin Greenberg, Elliot Frohman, Nitin Karandikar |
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| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 190:68.22-68.22 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.190.supp.68.22 |
| Popis: | Daily subcutaneous administration of FDA-approved glatiramer acetate (GA) has beneficial effects on clinical course of relapsing remitting multiple sclerosis (RRMS). Although mechanism of GA-action has been widely investigated and partially understood, immediate immune dynamics following GA-therapy and their significance are unknown. In the present study we characterized immediate effects of GA on phenotype, quantity and function of immune cell subsets in MS patients. PBMC from RRMS patients, either untreated or initiating GA, and healthy donors were obtained at time of admission and subsequently at 4h, 12h, 24h and 72h after first GA-injection. Prominent changes in immune cells were detected within 4-12h post first GA-injection. T-cell modulation included significantly decreased CD4/CD8 ratio, perturbation in homeostasis of predominantly CD8+ T-cells, significant enhancement in CD8+ T-cell mediated suppression and inhibitory potential of induced CD4-suppressors. Changes in APCs were restricted to monocytes and included reduced stimulatory capacity in MLR and significantly increased IL-10 and TNF-α. Our study provides first evidence that GA induced rapid immunologic changes even after first dose. Interestingly, these responses are not restricted to APCs but also include complex modulation of T-cell functionality. Long-term studies will evaluate sustenance of these effects over time and their significance in clinical efficacy of therapy. |
| Databáze: | OpenAIRE |
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