Antimyosin antibody imaging in experimental aortic regurgitation1
| Autor: | Mark Morgan, Edmund M. Herrold, Raffaele Gentile, Jeffrey S. Borer, Steven M. Goldfine, Pat B. Zanzonico, NM Magid, Ruth Hardoff, Ping Lu |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Pathology Cardiac output Necrosis business.industry Volume overload Regurgitation (circulation) medicine.disease In vivo Internal medicine Heart failure Monoclonal Cardiology Medicine Radiology Nuclear Medicine and imaging Systole medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of Nuclear Cardiology. 4:25-32 |
| ISSN: | 1071-3581 |
| DOI: | 10.1016/s1071-3581(97)90046-5 |
| Popis: | Fiber dropout and myocyte necrosis precede heart failure in experimental aortic regurgitation (AR). The current study aimed to determine whether this process can be detected by noninvasive scintigraphic imaging. 111In-labeled antimyosin antibody Fab fragment (1 to 1.5 mCi) (Myoscint) was administered to each of 34 New Zealand White rabbits: 11 early (3 to 5 weeks) after surgical AR induction; 9 late (98 to 128 weeks) after AR induction; 5 normal and 3 sham-operated age-matched with early AR; and 3 normal and 3 sham-operated age-matched with late AR. Echocardiographic fractional shortening was indistinguishable among control, early AR, and late AR groups. In vivo gamma camera imaging 24 and 48 hours after isotope administration, post-mortem heart activity determination (percentage injected dose per gram), and autoradiography were performed. At 24 and 48 hours, heart-to-lung counts-per-pixel ratios from in vivo images were greater (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink