Hypothalamic energy metabolism is impaired by doxorubicin independently of inflammation in non-tumour-bearing rats

Autor:	Bruno Rodrigues, Andrea Maculano Esteves, José Cesar Rosa Neto, Emilio L. Streck, Cinara L. Gonçalves, Fábio Santos Lira, Cláudio T. De Souza, Barbara de Moura Mello Antunes, Gustavo D. Pimentel, Lila Missae Oyama, Marco Túlio de Mello, Ronaldo Vagner dos Santos
Rok vydání:	2015
Předmět:	medicine.medical_specialty medicine.medical_treatment Clinical Biochemistry Interleukin Inflammation Cell Biology General Medicine Anorexia Metabolism Biology Biochemistry Malate dehydrogenase Endocrinology Cytokine Hypothalamus Internal medicine medicine Doxorubicin medicine.symptom medicine.drug
Zdroj:	Cell Biochemistry and Function. 33:393-397
ISSN:	0263-6484
Popis:	We sought to explore the effects of doxorubicin on inflammatory profiles and energy metabolism in the hypothalamus of rats. To investigate these effects, we formed two groups: a control (C) group and a Doxorubicin (DOXO) group. Sixteen rats were randomly assigned to either the control (C) or DOXO groups. The hypothalamus was collected. The levels of interleukin (IL)-1β, IL-6, IL-10, TNF-α and energy metabolism (malate dehydrogenase, complex I and III activities) were analysed in the hypothalamus. The DOXO group exhibited a decreased body weight (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6b01d59ebbb0037c8b22647fe410c8e8 https://doi.org/10.1002/cbf.3127 Zobrazit plný text záznamu Plný text