The effect of surface treatment on the brain delivery of curcumin nanosuspension: in vitro and in vivo studies
| Autor: | Behjat Sheikholeslami, Mohammad-Reza Rouini, Rassoul Dinarvand, Mahdi Gholami, Maryam Dibaei |
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| Rok vydání: | 2019 |
| Předmět: |
Biodistribution
Chromatography Organic Chemistry Biophysics Pharmaceutical Science Bioengineering 02 engineering and technology General Medicine Absorption (skin) Polyethylene glycol 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Bioavailability Biomaterials chemistry.chemical_compound chemistry Pharmacokinetics In vivo Drug Discovery Curcumin Distribution (pharmacology) 0210 nano-technology |
| Zdroj: | International Journal of Nanomedicine. 14:5477-5490 |
| ISSN: | 1178-2013 |
| DOI: | 10.2147/ijn.s199624 |
| Popis: | Background: Curcumin, a bioactive component with multiple characteristics, has been shown to have many therapeutic effects. However, there are several limitations regarding the use of curcumin such as instability, low solubility, poor bioavailability, and rapid elimination. Different approaches have been used to solve these problems. Materials and methods: In this study, surface-modified nanosuspension (NS) is investigated as a novel brain delivery system. Two different methods were used for the preparation of nanosuspensions with two different stabilizers. The surface of the nanosuspensions was coated with D-α-tocopheryl polyethylene glycol 1,000 succinate (TPGS) and Tween 80 using physical adsorption. Curcumin NSs were prepared using two different top-down techniques by high-pressure homogenizer and probe sonicator. A validated sensitive and selective high-performance liquid chromatography method using fluorescence detection was used for the determination and quantification of curcumin. Pharmacokinetics and biodistribution of curcumin NSs and solutions after intravenous administration in rats were studied. Results: Higher levels of curcumin in the brain were detected when Tween 80-coated NS was used compared with the curcumin solution and TPGS coated NS (TPGS-NS) (P-value |
| Databáze: | OpenAIRE |
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