Plasma-soluble Fas (APO-1, CD95) and soluble Fas ligand in immune thrombocytopenic purpura
| Autor: | Chie Yoshimura, Yoshio Ozaki, Minori Nagahama, Shirou Fukuhara, Shosaku Nomura, Hideo Kagawa |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
education.field_of_study Lymphocyte T cell Population Hematology General Medicine Biology Fas receptor Fas ligand Immune system medicine.anatomical_structure Endocrinology immune system diseases hemic and lymphatic diseases Internal medicine Immunology medicine Cytotoxic T cell education CD8 |
| Zdroj: | European Journal of Haematology. 64:219-224 |
| ISSN: | 0902-4441 |
| Popis: | We investigated the levels of various cytokines and soluble factors in ITP patients, in order to determine the influence of these factors on the pathogenesis of ITP. We found increases in IL-2, IL-6, IFN-γ, and M-CSF levels in ITP patients compared with those in healthy individuals. On lymphocyte phenotype analysis, we found no clear difference in total T cell population (CD2 + CD19 cells) or cytotoxic T cell frequency (CD8 CD11b cells) between these two groups. The frequency of helper/inducer T cells (CD4 CD8 cells) was decreased in ITP patients. There was a significant increase in activated T cells (CD3 + HLA-DR cells) in ITP patients. Furthermore, frequencies of NK cells of potent activity (CD16 + CD56 + cells) were significantly elevated in ITP patients. Seventeen of the 54 ITP patients (31.5%) had elevated levels of sFas, and 11 of the 54 patients (20.4%) of sFasL. In addition, a significant increase of sFasL was observed in sFas-positive ITP patients, and in these patients the sFasL level was correlated with that of sFas (r=0.687, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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