A new seco-pimarane diterpene and four new β-resorcylic acid lactones from a fungicolous Hypomyces subiculosus
| Autor: | Junjie Han, Jinwei Ren, Wenying Zhuang, Li Bao, Li Liu, Zhaoqing Zeng, Hongwei Liu, Buddha Bahadur Basnet, Ruixing Liu |
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| Rok vydání: | 2017 |
| Předmět: |
Hypomyces subiculosus
Bicyclic molecule 010405 organic chemistry Chemistry Stereochemistry General Chemical Engineering General Chemistry 010402 general chemistry Cleavage (embryo) Ring (chemistry) 01 natural sciences 0104 chemical sciences chemistry.chemical_compound Organic chemistry Diterpene Cytotoxicity Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | RSC Advances. 7:51986-51992 |
| ISSN: | 2046-2069 |
| DOI: | 10.1039/c7ra11365j |
| Popis: | One new pimarane diterpene (1) and four new β-resorcylic acid lactones (2–5), together with eight known compounds (6–13) were isolated from the solid culture of the fungicolous Hypomyces subiculosus. The structures of the new compounds were elucidated using extensive spectroscopic methods, including 1D and 2D NMR, HRESIMS, CD experiments, and chemical means. Compound 1 is a ring cleavage pimarane diterpene possessing a bicyclic ring system. All compounds were evaluated for cytotoxic activities. Only compound 7 showed moderate cytotoxicity against the A549 cell line with an IC50 of 44.5 μM. |
| Databáze: | OpenAIRE |
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