Prolonged release of metformin by SiO2 nanoparticles pellets for type II diabetes control
| Autor: | Eleazar M. Escamilla-Silva, J.F. Louvier-Hernández, Emmanuelle Perez, Rosalba Patiño-Herrera, Julie Chaumel, Alma Gabriela Palestino Escobedo |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Drug
endocrine system diseases media_common.quotation_subject Pellets Pharmaceutical Science 02 engineering and technology Pharmacology 030226 pharmacology & pharmacy Chitosan 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Adsorption Diabetes mellitus medicine media_common digestive oral and skin physiology nutritional and metabolic diseases Mesoporous silica 021001 nanoscience & nanotechnology medicine.disease Controlled release Metformin chemistry 0210 nano-technology medicine.drug |
| Zdroj: | European Journal of Pharmaceutical Sciences. 131:1-8 |
| ISSN: | 0928-0987 |
| DOI: | 10.1016/j.ejps.2019.02.003 |
| Popis: | Mesoporous silica nanoparticles (MSNPs) were synthesized and loaded with metformin hydrochloride (Metf), its adsorption has studied at different concentrations and pHs, optimal adsorption conditions were determined. Hybrid MSNPs-Metf were mixed with chitosan to compress them and form quasi-spherical pellets, were coated with five chitosan layers as a barrier to prolong metformin release. It showed that this pellet is useful for metformin controlled release since drug over time was significantly delayed by the chitosan coating and then, as metformin is electrostatically linked to MSNPs, it also controls the release of drug, releasing 170 mg after 17 h of exposure at pH 1.2. When pH is >1.2, metformin release was significantly prolonged. Since 170 mg is 21% of a 850-mg metformin dose and previous studies report that 90% of metformin is recovered as unchanged drug in urine after 12 h of metformin intakes. These results suggest that MSNPs-Metf pellets, coated with chitosan, are an option to avoid excessive metformin ingest. |
| Databáze: | OpenAIRE |
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