Efficient Fluoride-Mediated Synthesis of 5-Amino-Substituted Isothiazoles

Autor:	Yu. S. Zubenko, Vladimir I. Potkin
Rok vydání:	2009
Předmět:	chemistry.chemical_compound Isothiazole chemistry Organic Chemistry Substitution (logic) Nucleophilic substitution Amine gas treating Fluoride Medicinal chemistry Catalysis
Zdroj:	Synthesis. 2009:2361-2364
ISSN:	1437-210X 0039-7881
DOI:	10.1055/s-0029-1216844
Popis:	Fluoride-mediated nucleophilic substitution reactions of tert-butyl 4,5-dichloroisothiazole-3-carboxylate with various amines occur under mild conditions yielding 5-(alkylamino)isothiazoles in moderate to high yields.
Databáze:	OpenAIRE
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